NSF and AMPA Receptors Get Physical
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چکیده
منابع مشابه
NSF and AMPA Receptors Get Physical
the vesicle expresses a specific membrane protein Department of Neurobiology (v-SNARE) that binds to a cognate receptor on the target Howard Hughes Medical Institute membrane (t-SNARE). For synaptic vesicle exocytosis, Massachusetts General Hospital the v-SNARE VAMP/synaptobrevin, an integral mem-and Harvard Medical School brane protein of the synaptic vesicle, interacts with the Boston, Massac...
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The trafficking of AMPA receptors (Rs) to and from synaptic membranes is a key component underlying synaptic plasticity mechanisms such as long-term potentiation (LTP) and long-term depression (LTD), and is likely important for synaptic development in embryonic organisms. However, some of the key biochemical components required for receptor trafficking in embryos are still unknown. Here, we rep...
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Here, we show that disruption of N-ethylmaleimide-sensitive fusion protein- (NSF-) GluR2 interaction by infusion into cultured hippocampal neurons of a blocking peptide (pep2m) caused a rapid decrease in the frequency but no change in the amplitude of AMPA receptor-mediated miniature excitatory postsynaptic currents (mEPSCs). N-methyl-D-aspartate (NMDA) receptor-mediated mEPSCs were not changed...
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Luscher et al., 1999). This indicates that NSF maintains form a complex in the presence of ATP␥S. Similar a high level of synaptic AMPARs, either by preventing to SNARE complex disassembly, NSF ATPase activity their removal by endocytosis or facilitating their insertion disrupts PICK1-GluR2 interactions in this complex. ␣-by exocytosis. The same peptide treatment occludes and -SNAP have differ...
متن کاملNomadic AMPA Receptors and LTP
leased glutamate could explain the electrophysiological changes observed during LTP that have been attributed to an increase in presynaptically released neurotrans-Long-term potentiation (LTP) is one of the most widely mitters. In support of the silent synapse hypothesis, studied topics in neuroscience today. LTP refers to a electrophysiological and immunohistochemical studies long-lasting incr...
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ژورنال
عنوان ژورنال: Neuron
سال: 1998
ISSN: 0896-6273
DOI: 10.1016/s0896-6273(00)80534-6